Our memories define us and connect us to others. Without them, we are lost. This is the driving force behind the global push to treat neurodegenerative diseases of the older population. How does one know they have a disease that has few outward symptoms until later stages? The current testing methods for diseases such as Alzheimer’s and Parkinson’s require a spinal tap and imaging tests such as MRI. This has made early detection of these diseases an incredible challenge. This work highlights a DNA aptamer-modified graphene field-effect transistor biosensor to detect unprocessed biomarker proteins in easily accessible biofluids derived from patients with Alzheimer’s disease, in pursuit of an affordable early-onset detection of neurodegenerative diseases.
“Am I positive or negative?” Everyone wants to know the answer with speed and accuracy. Rapid and accurate at-home testing is the best defense against the COVID-19 pandemic and ensuing endemics. Current rapid tests are often imprecise, test for denatured and processed viral components, and lack specificity for new variants. We developed a simple at-home test using saliva swabs that answers “positive or negative” in minutes and transmits results to stakeholders. The test uses a DNA aptamer-derivatized graphene field-effect transistor (GFET) to detect unprocessed intact SARS-CoV-2 and its variants at levels as low as 7 to 10 viruses. This method is tunable and adaptable for early-stage detection of emerging viral infections as well as many diseases with accessible biofluids.
Our electrical sensor-based SNP detection technology, without labeling and without apparent cross-hybridization artifacts, allows fast, sensitive, and portable SNP detection with single-nucleotide resolution. The technology has a wide range of applications in digital and implantable biosensors and high-throughput DNA genotyping, with transformative implications for personalized medicine.
Our Mission:
Life in Your Hand
Make Biosensor diagnostics affordable and available globally.
We have translated physical, chemical and biochemical sciences to electronics technology, using graphene and single-strand nucleic acids to achieve PCR-level precision.
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